What is an important consideration when administering antihistamines to elderly patients?

Elderly patients often have physiological changes that affect drug metabolism and increase their susceptibility to side effects. Antihistamines can cause sedation, confusion, and dry mouth, which can be particularly concerning in older adults who may already be dealing with cognitive impairment or other health issues.

As individuals age, their liver and kidney functions may decline, which can affect how drugs are processed and eliminated from the body. This can lead to a greater accumulation of medication in the system, heightening the risk of adverse effects. Additionally, the presence of multiple comorbidities and the use of polypharmacy in elderly populations can further complicate medication management.

Therefore, when administering antihistamines to elderly patients, it is crucial to consider these factors to minimize the risk of side effects and ensure safe and effective treatment. This focus on the increased susceptibility to side effects emphasizes the need for careful monitoring and potential dose adjustments as necessary.